Sr. Associate Scientist II, On-Target NGS

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Prime Medicine is seeking an experienced, dependable and dedicated Associate Scientist / Senior Associate Scientist who is well-versed in Next Generation Sequencing with experience in a GMP environment to join the cross-collaborative and purpose-drive On-Target NGS team in supporting Prime Medicine’s drug discovery and development pipeline. The role requires in-depth technical knowledge of and experience with NGS sample processing and Illumina sequencing. The successful candidate will support the implementation and optimization of automated NGS library workflows as well as Illumina sequencer operation. Experience in executing high-throughput genomics workflows for both GMP testing and R&D experiments is ideal.

• →Support the execution, development and validation of GMP and R&D NGS-based workflows.
• →Operation, regular maintenance and troubleshooting of automated liquid handlers and Illumina sequencers.
• →Tracking and documentation of instrument maintenance, NGS reagents, samples and sequencing QC metrics in LIMS systems.
• →Collaborate closely with R&D scientists, automation, informatics and bioinformatics to execute R&D sample submissions using high-throughput NGS.
• →Drive the transition of assays from development to production by working with members of the R&D and automation teams.
• →Perform other related duties and ad hoc projects as required by position and in support of the On-Target NGS team.

• S./M.S. in molecular biology, biotechnology, or other relevant scientific degree.
• 4+ years of hands-on experience in NGS library preparation and sequencing.
• 2+ years of experience in a GMP lab
• Technical experience with Illumina sequencing platforms.
• Experience using a LIMS system for sample tracking and processing and experimental documentation.
• Excellent attention to detail and a commitment to producing high-quality NGS data.
• Experience with laboratory automation, particularly NGS on liquid handlers, is a plus.
• Assay validation and implementation experience, is a plus.