Senior Scientist - siRNA Therapeutics

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.  As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this role you will join the Genetic Medicines team in Thousand Oaks, CA. As a new member of this team, you will be responsible for generating and implementing novel methods to deliver RNA-based therapies to previously unreachable cellular destinations across Amgen’s therapeutic areas.

• →Help identify and implement new technologies to accelerate discovery at the leading edge of targeted delivery

• →Generate and bring to life new approaches for realizing how extrahepatic RNA therapeutics can be deployed

• →Collaborate closely with disease area, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert

• →Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an enthusiastic scientist with these qualifications.

Doctorate degree PhD OR PharmD 

• PhD or Master’s in molecular biology, cell biology, RNA biology or a related discipline, with relevant industry or equivalent research experience in oligonucleotide therapeutics and/or genetic medicines.
• Experience performing high-throughput cell-based screening and generating sequencing-based screening data using methods such as Drug-seq, including sample preparation and quality control.
• Experience designing and executing studies of extrahepatic siRNA delivery using antibody-siRNA conjugates and other delivery modalities, including in vivo study design, execution, sample processing and data interpretation.
• Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant scientific contributions.

Ability to serve as a subject matter expert and representative on cross-functional project teams: communicate data and recommendations clearly, coordinate with one or more therapeutic areas, and translate project questions into experimental plans including

Master’s degree and 2 years of relevant scientific experience

Bachelor’s degree and 4 years of relevant scientific experience

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen anticipates accepting applications until 1 week after the posting; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.