Group Lead, Immunology

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

NewLimit is seeking an immunologist with leadership experience in therapeutics to lead our Immunology team. Our Immunology program is developing reprogramming medicines to restore youthful function in aged T cells for the treatment of inflammatory & infectious diseases with a strong emphasis on T cell and regulatory T cell (Treg) biology.

As the leader of Immunology team, you will:

• →Lead a team of Scientists and Research Associates to develop reprogramming therapies
• →Develop functional assays and pre-clinical models for inflammatory and infectious disease indications
• →Evaluate reprogramming payloads using functional assays & pre-clinical models to validate payloads, select leads, and progress pre-clinical candidates
• →Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test reprogramming interventions
• →Contribute to NewLimit’s product development decisions, company-wide goals, and technology platform. You will be a key part of building the company in addition to your team.
• →Contribute to day-to-day execution alongside your team. Everyone Executes at NewLimit.

• Ph.D. in cell biology, immunology, or a related field or comparable industry experience
• Experience leading a team and managing direct reports
• Experience with therapeutics development, ideally leading a portion of a discovery or development process in an immunology, infectious disease, or inflammatory disease setting
• Deep knowledge of immunology & lymphocyte biology

• Direct experience with T cell biology, including relevant functional assays, pre-clinical models, and experimental methods
• Experience with in vivo nucleic acid delivery technologies
• Experience with pooled screening and related functional genomics methods
• Strong molecular biology foundations and experience designing transgenic constructs
• Experience with iterative product development cycles (e.g. design-build-test-learn)
• Knowledge of aging biology, computational biology, and machine learning