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HomeJobsLocationsUnited States

Principal Jobs in United States

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Showing 20 of 361 jobs
marianaoncologymarianaoncology·United StatesUnited States·On-site

Principal Scientist I, Medicinal Chemistry

From $202k/year
37
Lowest

Description: Mariana Oncology is seeking a Principal Scientist I, Medicinal Chemistry to join our Discovery Chemistry team. The successful candidate will play a key role in advancing innovative radiopharmaceutical and precision medicine programs, with a focus on peptide-based therapeutics. This indi

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5 0 0 17d ago
marianaoncology
marianaoncology·United StatesUnited States

Principal Scientist I, Medicinal Chemistry

OtherPrincipalFull-TimeLead
From $202k
/year
37
Lowest
17d ago
5 views0 saves 0 applied

Description: Mariana Oncology is seeking a Principal Scientist I, Medicinal Chemistry to join our Discovery Chemistry team. The successful candidate will play a key role in advancing innovative radiopharmaceutical and precision medicine programs, with a focus on peptide-based therapeutics. This indi

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5 views0 saves0 applied
17d ago
eagle aseagle as·United StatesUnited States·On-site

Principal

$200k–$250k/year
32
Lowest

🦅 About Eagle Eagle is on a mission to re-energize the engineering profession. Every road, water system, and power grid starts at an engineering firm. There are 45,700 of them in the US, and most run on software older than the engineers using it. We partner deeply with engineering firms and build an

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8 0 0 22d ago
eagle as
eagle as·United StatesUnited States

Principal

OtherOf StaffPrincipalFull-TimeLead
$200k–$250k
/year
32
Lowest
22d ago
8 views0 saves 0 applied

🦅 About Eagle Eagle is on a mission to re-energize the engineering profession. Every road, water system, and power grid starts at an engineering firm. There are 45,700 of them in the US, and most run on software older than the engineers using it. We partner deeply with engineering firms and build an

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8 views0 saves0 applied
22d ago
N
Nanopath·United StatesUnited States·On-site

V&V Senior Scientist / Principal Scientist

23
Lowest

Nanopath is developing a first-in-class in vitro diagnostics platform to transform how diseases are diagnosed. We aim to replace lengthy molecular testing workflows by bringing rapid, high-quality diagnostics closer to the patient. Our mission is to improve patient outcomes – starting with women – t

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5 0 0 27d ago
N
Nanopath·United StatesUnited States

V&V Senior Scientist / Principal Scientist

OtherPrincipalSenior
23
Lowest
27d ago
5 views0 saves 0 applied

Nanopath is developing a first-in-class in vitro diagnostics platform to transform how diseases are diagnosed. We aim to replace lengthy molecular testing workflows by bringing rapid, high-quality diagnostics closer to the patient. Our mission is to improve patient outcomes – starting with women – t

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5 views0 saves0 applied
27d ago
kearneykearney·United StatesRemote · open to United States

Kearney Healthcare & Life Sciences Practice Principal (Pharma R&D Strategy)

27
Lowest

As a Principal within Kearney’s Healthcare & Life Sciences Practice, you will play a key role in driving the growth and development of our Pharma R&D Strategy offering. You will work closely with senior clients and internal teams to develop strategic insights and deliver high-impact outcomes across

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4 0 0 ~29d ago
kearney
kearney·United StatesRemote · open to United States

Kearney Healthcare & Life Sciences Practice Principal (Pharma R&D Strategy)

OtherPrincipalLead
27
Lowest
~29d ago
4 views0 saves 0 applied

As a Principal within Kearney’s Healthcare & Life Sciences Practice, you will play a key role in driving the growth and development of our Pharma R&D Strategy offering. You will work closely with senior clients and internal teams to develop strategic insights and deliver high-impact outcomes across

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4 views0 saves0 applied
~29d ago
P
Psivant·United StatesUnited States·Hybrid

Principal Scientist, Medicinal Chemistry

$170k–$200k/year
37
Lowest

PsiThera is seeking a talented and creative medicinal chemist with strong hands-on experience advancing discovery programs from hit identification through development candidate nomination. This candidate will bring deep expertise in synthetic and medicinal chemistry, with a demonstrated track record

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3 0 0 2mo ago
P
Psivant·United StatesUnited States·Hybrid

Principal Scientist, Medicinal Chemistry

OtherPrincipalFull-TimeLead
$170k–$200k
/year
37
Lowest
2mo ago
3 views0 saves 0 applied

PsiThera is seeking a talented and creative medicinal chemist with strong hands-on experience advancing discovery programs from hit identification through development candidate nomination. This candidate will bring deep expertise in synthetic and medicinal chemistry, with a demonstrated track record

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3 views0 saves0 applied
2mo ago
evolvconsultingevolvconsulting·United StatesUnited States·Remote · United States

Principal (Solution Owner Skillset)

29
Lowest

Do you want to support innovative clients at the intersection of cutting-edge technologies and impactful relationships? evolv’s culture of integrity, humility, passion, and drive and have been named "Best Places to Work" by Dallas Business Journal in 2021 and 2022, "Top Workplaces" by Dallas Morning

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4 0 0 3mo ago
evolvconsulting
evolvconsulting·United StatesUnited States·Remote

Principal (Solution Owner Skillset)

OtherPrincipalLead
29
Lowest
3mo ago
4 views0 saves 0 applied

Do you want to support innovative clients at the intersection of cutting-edge technologies and impactful relationships? evolv’s culture of integrity, humility, passion, and drive and have been named "Best Places to Work" by Dallas Business Journal in 2021 and 2022, "Top Workplaces" by Dallas Morning

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4 views0 saves0 applied
3mo ago
UnqorkUnqork·United StatesUnited States·Remote · United States

Principal Customer Advocate Manager

$125k–$155k/year
43
Low

Unqork empowers enterprises to accelerate growth by rapidly building, testing, and running AI-powered applications that embody the future of enterprise development. Trusted by the world’s largest organizations in highly regulated industries, these applications become more secure over time while sign

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6 0 0 3mo ago
Unqork
Unqork·United StatesUnited States·Remote

Principal Customer Advocate Manager

OtherPrincipalLead
$125k–$155k
/year
43
Low
3mo ago
6 views0 saves 0 applied

Unqork empowers enterprises to accelerate growth by rapidly building, testing, and running AI-powered applications that embody the future of enterprise development. Trusted by the world’s largest organizations in highly regulated industries, these applications become more secure over time while sign

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6 views0 saves0 applied
3mo ago
Career-CollectiveCareer-Collective·United StatesUnited States·On-site

Principal

17
Lowest

Principal Summary We are seeking a dynamic Principal to join our team. This is an opportunity to expand the Education practice across our Carolina markets and help shape the future of a growing, forward-thinking organization. This role will be pivotal in providing leadership to the Southeast region,

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3 0 0 ~3mo ago
Career-Collective
Career-Collective·United StatesUnited States

Principal

OtherPrincipalLead
17
Lowest
~3mo ago
3 views0 saves 0 applied

Principal Summary We are seeking a dynamic Principal to join our team. This is an opportunity to expand the Education practice across our Carolina markets and help shape the future of a growing, forward-thinking organization. This role will be pivotal in providing leadership to the Southeast region,

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3 views0 saves0 applied
~3mo ago
L
Little Wise Kids Preschool·United StatesUnited States·On-site

Childcare Principal

23
Lowest

ABOUT THE ROLE As Principal, you’ll be responsible for the overall success of your school, leading operations, developing your team, and driving enrollment and performance. You’ll ensure a safe, compliant environment while delivering high-quality experience for c

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4 0 0 5mo ago
L
Little Wise Kids Preschool·United StatesUnited States

Childcare Principal

OtherPrincipalLead
23
Lowest
5mo ago
4 views0 saves 0 applied

ABOUT THE ROLE As Principal, you’ll be responsible for the overall success of your school, leading operations, developing your team, and driving enrollment and performance. You’ll ensure a safe, compliant environment while delivering high-quality experience for c

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4 views0 saves0 applied
5mo ago
Metrum Research GroupMetrum Research Group·United StatesUnited States·Remote · US

PKPD Principal Scientist

30
Lowest

At Metrum Research Group, we combine cutting-edge science, data, and technology to solve complex challenges in drug development and healthcare innovation. We are seeking individuals with 10+ years of postdoctoral experience who thrive in collaborative, agile environments and are passionate about adv

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2 0 0 5mo ago
Metrum Research Group
Metrum Research Group·United StatesUnited States·Remote

PKPD Principal Scientist

OtherPrincipalLead
30
Lowest
5mo ago
2 views0 saves 0 applied

At Metrum Research Group, we combine cutting-edge science, data, and technology to solve complex challenges in drug development and healthcare innovation. We are seeking individuals with 10+ years of postdoctoral experience who thrive in collaborative, agile environments and are passionate about adv

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2 views0 saves0 applied
5mo ago
Mti IncMti Inc·United StatesUnited States·On-site

Principal Human Factors Engineer

23
Lowest

WE ARE: Monterey Technologies, Inc. applies human-centered systems engineering to the design and development of complex, critical systems. Our human modeling approach helps our clients deliver improved human and system performance at lower life cycle costs. Our human-centered approach to problem-sol

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7 0 0 6mo ago
Mti Inc
Mti Inc·United StatesUnited States

Principal Human Factors Engineer

OtherEngineerPrincipalFull-TimeLead
23
Lowest
6mo ago
7 views0 saves 0 applied

WE ARE: Monterey Technologies, Inc. applies human-centered systems engineering to the design and development of complex, critical systems. Our human modeling approach helps our clients deliver improved human and system performance at lower life cycle costs. Our human-centered approach to problem-sol

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7 views0 saves0 applied
6mo ago
opportunityeducationopportunityeducation·United StatesUnited States·On-site

Founding Principal

$135k–$145k/year
32
Lowest

Founding Principal | Opportunity Education Fishers, IN About the Organization Opportunity Education is a charitable foundation with the mission of developing and supporting life-changing learning programs for young adults worldwide. Founded in 2005 Opportunity Education has supported programs in 12

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15 0 0 25mo ago
opportunityeducation
opportunityeducation·United StatesUnited States

Founding Principal

OtherPrincipalLead
$135k–$145k
/year
32
Lowest
25mo ago
15 views0 saves 0 applied

Founding Principal | Opportunity Education Fishers, IN About the Organization Opportunity Education is a charitable foundation with the mission of developing and supporting life-changing learning programs for young adults worldwide. Founded in 2005 Opportunity Education has supported programs in 12

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15 views0 saves0 applied
25mo ago
hraadvisorshraadvisors·United StatesUnited States·On-site

Principal, Inclusive Cities

$156k–$184k/year
32
Lowest

ABOUT US | HR&A Advisors is an employee-owned advisory firm working at the intersection of government, philanthropy, and the built environment to advance equitable growth and quality of life in cities. Over the past decade, HR&A has increasingly partnered with city governments, public authorities, a

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7 0 0 ~1mo ago
hraadvisors
hraadvisors·United StatesUnited States

Principal, Inclusive Cities

OtherPrincipalLead
$156k–$184k
/year
32
Lowest
~1mo ago
7 views0 saves 0 applied

ABOUT US | HR&A Advisors is an employee-owned advisory firm working at the intersection of government, philanthropy, and the built environment to advance equitable growth and quality of life in cities. Over the past decade, HR&A has increasingly partnered with city governments, public authorities, a

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7 views0 saves0 applied
~1mo ago
Redapt Inc.Redapt Inc.·United StatesUnited States·On-site

Principal Security Advisor (vCISO)

23
Lowest

Principal Security Advisor (vCISO) Position Summary Redapt is seeking a Principal Security Advisor (vCISO) to join our vCTO practice and lead security-focused customer engagements. This role combines executive advisory, solution architecture, and delivery leadership responsibilities. The ideal candi

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8 0 0 1mo ago
Redapt Inc.
Redapt Inc.·United StatesUnited States

Principal Security Advisor (vCISO)

OtherPrincipalLead
23
Lowest
1mo ago
8 views0 saves 0 applied

Principal Security Advisor (vCISO) Position Summary Redapt is seeking a Principal Security Advisor (vCISO) to join our vCTO practice and lead security-focused customer engagements. This role combines executive advisory, solution architecture, and delivery leadership responsibilities. The ideal candi

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8 views0 saves0 applied
1mo ago
Omidyar NetworkOmidyar Network·United StatesUnited States·On-site

Principal, Programs and Policy (Tech and AI)

$171k–$214k/year
34
Lowest

About Omidyar Network (ON): Omidyar Network is a philanthropic organization whose mission is to bend the arc of the digital revolution toward shared power, prosperity, and possibility. Digital technology is a powerful and ubiquitous force that, harnessed wisely, makes wondrous things happen. We beli

OtherPrincipalLead
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7 0 0 5mo ago
Omidyar Network
Omidyar Network·United StatesUnited States

Principal, Programs and Policy (Tech and AI)

OtherPrincipalLead
$171k–$214k
/year
34
Lowest
5mo ago
7 views0 saves 0 applied

About Omidyar Network (ON): Omidyar Network is a philanthropic organization whose mission is to bend the arc of the digital revolution toward shared power, prosperity, and possibility. Digital technology is a powerful and ubiquitous force that, harnessed wisely, makes wondrous things happen. We beli

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7 views0 saves0 applied
5mo ago
R
Redding Ridge Asset Management·United StatesUnited States·On-site

Principal, CLO & Funds Securitization Counsel

From $300k/year
34
Lowest

About Redding Ridge Asset Management Redding Ridge Asset Management LLC (“Redding Ridge”) was established and seeded by Apollo Global Management, Inc. (together with its subsidiaries, “Apollo”) in 2016. Redding Ridge has assets under management of approximately $43.9 billion as of March 31, 2026. Re

OtherCounselPrincipalLead
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12 0 0 7mo ago
R
Redding Ridge Asset Management·United StatesUnited States

Principal, CLO & Funds Securitization Counsel

OtherCounselPrincipalLead
From $300k
/year
34
Lowest
7mo ago
12 views0 saves 0 applied

About Redding Ridge Asset Management Redding Ridge Asset Management LLC (“Redding Ridge”) was established and seeded by Apollo Global Management, Inc. (together with its subsidiaries, “Apollo”) in 2016. Redding Ridge has assets under management of approximately $43.9 billion as of March 31, 2026. Re

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12 views0 saves0 applied
7mo ago
VenteurVenteur·United StatesUnited States·On-site

Principal/Lead Fintech Engineer (Startup - Series A)

$190k–$265k/year
34
Lowest

About Venteur At Venteur, we’re rebuilding health insurance from the ground up—making it more affordable, portable, and human-centered. We partner with employers to move beyond one-size-fits-all group plans, giving employees tax-free dollars to choose the health coverage that works best for them. Be

OtherPrincipalFull TimeLead
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8 0 0 15mo ago
Venteur
Venteur·United StatesUnited States

Principal/Lead Fintech Engineer (Startup - Series A)

OtherPrincipalFull TimeLead
$190k–$265k
/year
34
Lowest
15mo ago
8 views0 saves 0 applied

About Venteur At Venteur, we’re rebuilding health insurance from the ground up—making it more affordable, portable, and human-centered. We partner with employers to move beyond one-size-fits-all group plans, giving employees tax-free dollars to choose the health coverage that works best for them. Be

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8 views0 saves0 applied
15mo ago
wearerallywearerally·United StatesUnited States·On-site

Principal

20
Lowest

CALLING ALL BIG-HEARTED, BIG THINKING PEOPLE ARE YOU READY TO DO THE BEST WORK OF YOUR LIFE? We seek strategists, creators, and communicators ready to do some heavy lifting—folks who aren’t afraid to break glass and who thrive in collaboration. Those who bring conviction but can still see both sides

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4 0 0 ~29d ago
wearerally
wearerally·United StatesUnited States

Principal

OtherPrincipalLead
20
Lowest
~29d ago
4 views0 saves 0 applied

CALLING ALL BIG-HEARTED, BIG THINKING PEOPLE ARE YOU READY TO DO THE BEST WORK OF YOUR LIFE? We seek strategists, creators, and communicators ready to do some heavy lifting—folks who aren’t afraid to break glass and who thrive in collaboration. Those who bring conviction but can still see both sides

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4 views0 saves0 applied
~29d ago
Antares TherapeuticsAntares Therapeutics·United StatesUnited States·On-site

Sr. ScientistII/Principal Scientist, Chemical Biology

$170k–$205k/year
34
Lowest

Salary Band: $170,000-$205,000 Location: Boston, MA Job Summary Antares Therapeutics is seeking an accomplished, technically driven Sr. Scientist II/ Principal Scientist to join our Chemical Biology team. This is a senior individual-contributor role for a proteomics and mass spectrometry expert who

OtherPrincipalSenior
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8 0 0 1mo ago
Antares Therapeutics
Antares Therapeutics·United StatesUnited States

Sr. ScientistII/Principal Scientist, Chemical Biology

OtherPrincipalSenior
$170k–$205k
/year
34
Lowest
1mo ago
8 views0 saves 0 applied

Salary Band: $170,000-$205,000 Location: Boston, MA Job Summary Antares Therapeutics is seeking an accomplished, technically driven Sr. Scientist II/ Principal Scientist to join our Chemical Biology team. This is a senior individual-contributor role for a proteomics and mass spectrometry expert who

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8 views0 saves0 applied
1mo ago
L
League Inc.·United StatesUnited States·On-site

Principal, Value Realization

$170k–$200k/year
34
Lowest

About League League is one of the fastest-growing technology companies in Canada and the leading healthcare experience platform. Getting healthcare is often the easy part — finishing it is where things fall apart: people book the appointment and skip the follow-up, fill the prescription and stop tak

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5 0 0 3mo ago
L
League Inc.·United StatesUnited States

Principal, Value Realization

OtherPrincipalLead
$170k–$200k
/year
34
Lowest
3mo ago
5 views0 saves 0 applied

About League League is one of the fastest-growing technology companies in Canada and the leading healthcare experience platform. Getting healthcare is often the easy part — finishing it is where things fall apart: people book the appointment and skip the follow-up, fill the prescription and stop tak

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5 views0 saves0 applied
3mo ago
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About Principal jobs in United States

As of Oct 26, 2026, Jobera lists 361 open Principal jobs in United States, collected from employers’ own career sites. 12% of them are fully remote. Where pay is stated in US dollars, the median is $185,000 a year (based on 132 job postings). Most openings are in New York, San Francisco and San Jose.

How many Principal jobs are open in United States?

As of Oct 26, 2026, Jobera lists 361 open Principal jobs in United States, collected from employers’ own career sites.

Are Principal jobs in United States remote?

12% of them are fully remote.

What do Principal jobs in United States pay?

Where pay is stated in US dollars, the median is $185,000 a year (based on 132 job postings).

Which companies are hiring for Principal jobs in United States?

Employers with the most openings: Hut8, Apex Companies and CSG Consultants, Inc..

Where are most Principal jobs located?

Most openings are in New York, San Francisco and San Jose.