People Operations Manager

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

BillionToOne is looking for a People Operations Manager to join our growing People team and play a critical role in scaling our people programs, systems, and operations. This role will own and enhance core People Ops programs while serving as a key partner in driving operational excellence, vendor strategy, and data-informed decision-making.

The ideal candidate brings deep expertise in benefits, strong program and project management skills, and a data-driven mindset, with the ability to anticipate needs and proactively improve processes in a fast-paced, high-growth environment.

This is a hybrid role (2–3 days onsite per week at our Menlo Park and/or Union City office) reporting to the Associate Director of People Operations.

• →Design, optimize, and scale core People Ops programs (onboarding, offboarding, performance cycles, engagement/recognition, and compliance), driving strategy, scalability, and continuous improvement
• →Own and scale benefits strategy and operations, serving as the primary lead for vendor partnerships (benefits brokers, payroll providers, etc.)
• →Act as the program manager for performance cycles, driving end-to-end execution, stakeholder alignment, and continuous improvement
• →Design and implement scalable processes and systems, proactively identifying gaps and driving operational efficiency
• →Partner with the Associate Director to operationalize strategic initiatives (e.g., recognition program, engagement survey, etc.)
• →Maintain strong policy and compliance knowledge, recommending updates to enhance both compliance and employee experience
• →Serve as the Tier 2 escalation point for complex employee inquiries, resolving issues independently and escalating only critical matters as needed

• 5+ years of experience in People Operations, HR Generalist, or similar roles, preferably in a high-growth or startup environment
• Strong expertise in benefits administration and vendor management
• Proven experience leading cross-functional programs or cycles (e.g., performance management, compensation, or engagement programs)
• Demonstrated ability to design and improve scalable processes and systems
• Strong analytical skills with experience using data to drive decisions
• Excellent project management, organizational, and prioritization skills
• Strong communication skills with the ability to influence and partner across levels
• High attention to detail, sound judgment, and a proactive mindset
• “Scrappy,” solutions-oriented approach with a focus on continuous improvement
• Previous experience in start-up is highly desired

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

From $0 to $150M+ in Annual Recurring Revenue in just five years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com